L-Citrulline is an amino acid that supports the body in optimizing blood flow through its conversion to L-arginine and then nitric oxide. Nitric oxide is involved in vasodilatation and low levels are associated with mental and physical fatigue and sexual dysfunction. L-Citrulline (like L-Arginine and L-Ornithine), is a metabolite in the urea cycle and is involved in liver detoxification and vasodilation pathways. It is produced in the urea cycle when carbamoyl phosphate is converted to L-citrulline in the ornithine carbamoyltransferase reaction. When endogenous supplies of ornithine carbamoyltransferase are insufficient, supplemental L-citrulline has been shown to support ammonia incorporation and liver detoxification of ammonia. Free form amino acid, high purity, well tolerated. For additional support, one may include Magnesium Malate Forte.
L-Citrulline was first isolated from watermelon. It was named after citrullus which is the latin for watermelon. L-Citrulline is a nonessential amino acid, which is not found in dietary protein. L-Citrulline is a precursor to the formation of L-Arginine and thus plays a vital role in Arginine recycling, which is an important factor in nitric oxide release.
Citrulline supplementation provides a readily available source of citrulline for this purpose, and some recent research further indicates that citrulline may even be the preferred source of cellular Arginine. Citrulline is one of the key elements to Nitric Oxide production that is overlooked. L-Citrulline is involved in the catabolism of the amino acid, L-arginine. In bacteria, the arginine dihydrolase pathway deaminates arginine to citrulline and splits citrulline into ornithine and carbamoyl phosphate. This pathway is a source of energy for many microorganisms and is used as an identifying test.
Oral Citrulline supplementation provides a readily available source of Citrulline for this purpose, and some recent research further indicates that Citrulline may be the preferred source of cellular Arginine. In addition Citrulline also increases energy, stimulates the immune system, and is essential for Urea Cycle function as well.
As a dietary supplement, 1 and 1/4 teaspoons two times daily, or as directed by a healthcare practitioner.
Contraindicated for individuals with kidney abnormalities, a hypersensitivity to L-citrulline and for children under 12 years of age.
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